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KMID : 0363220080460101435
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Korean Journal of Dermatology
2008 Volume.46 No. 10 p.1435 ~ p.1438
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A Case of Drug Eruption with Localized Exfoliative Dermatitis Induced by Imatinib Mesylate
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Yoo Kwang-Ho
Rho Yong-Kwan
Kim Ji-Young
Li Kap-Sok
Seo Seong-Jun
Hong Chang-Kwun
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Abstract
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Imatinib mesylate (Gleevecⓡ, formerly known as STI571) is a protein-tyrosine kinase inhibitor that inhibits the
bcr-abl tyrosine kinase created by the Philadelphia chromosome abnormality in patients with chronic myeloid leukemia
(CML). Between 7 to 21% of the patients treated with imatinib mesylate have been reported to develop adverse
cutaneous reactions. However, exfoliative dermatitis related to imatinib mesylate is rare and there is only one previously
reported case of this in the Korean literature. We report here on a woman with localized exfoliative dermatitis that
developed after administering imatinib mesylate for treating her CML.
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KEYWORD
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Imatinib mesylate, Localized exfoliative dermatitis
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